Some guards may implement some logic based on extra signatures on top the required ones (“required” meaning equal to the threshold of the Safe). Currently the only way (that I know of, please correct me if I am wrong!) to provide such additional signatures to the Safe contract is via a custom UI.
It would be nice if the standard Safe UI would allow this, it seems to be a minor feature given the signature gathering logic is already implemented.
Note: I have implemented such a guard and had to implement such a custom UI, I guess I am not the only one. For instance I expect the SafenetGuard to also need such logic to gather the signature of the verifier.